Why this coenzyme is so important for the body
Coenzyme Q10, also abbreviated as Q10, was known primarily through the cosmetic industry. However, it is important not only for our skin, but also for every one of the approximately 37 billion cells in our body. It is found in particular in the “powerhouses of the cells” ‒ the mitochondria ‒ where around 90% of all of the energy for our body is produced. And this energy is used for nearly all of the processes in our body – without energy, these processes cannot run.
Our body can form Q10 itself, however studies show that the body’s own Q10 production continuously decreases starting at around age 20. Moreover, stress, competitive sports, an unhealthy lifestyle, smoking, and taking certain medications, for example, can increase this process. Apart from a healthy diet, taking a nutritional supplement may be useful to systematically counteract a Q10 deficiency.
Why this coenzyme is so important for the body
Coenzyme Q10 was discovered in 1955 and it is a fat-soluble, vitamin-like substance which can be produced by our body itself and which is also ingested through food. It is an odourless, tasteless crystalline substance which belongs to the ubiquinone family.
Q10 is found in all cells of the body and in the mitochondria in particular. Vital energy is formed in the mitochondria from food. Organs with a high energy requirement, such as the heart, brain, muscles, liver and kidneys, have a particularly high concentration of Q10.
Q10 is also notably present in membranes which surround the inside of cells and cell organelles like a shell. The exchange of substances such as sodium, potassium and calcium ions and the transfer of information, among other things, are regulated via these membranes. Q10 – along with the also valuable omega-3 fatty acids – largely determines the quality of the membranes.
Ubiquinol And Ubiquinone – The Difference
Coenzyme Q10 is present in our body in two biochemical forms: in the oxidised form as ubiquinone which is conventionally also simply referred to as coenzyme Q10, and also as ubiquinol in the reduced form. Both forms play a role in energy production in the mitochondria. In other areas of the body, such as in the blood and lymph, around 90% of Q10 is present in the reduced form as ubiquinol.
In our body, Q10 is primarily formed in the liver, however this is also fundamentally possible in all other organs and tissues.
In a multistep process, Q10 arises in the form of ubiquinone from mevalonic acid and the amino acids tyrosine and methionine as well as with the aid of vitamins B3, B6, B12, folic acid and pantothenic acid.
During energy production in the mitochondria, ubiquinone, as a mobile transport molecule, can absorb electrons from one protein complex and transfer them to another. This results in ubiquinol which becomes ubiquinone once again after releasing the electrons and which is ready to absorb electrons again.
Coenzyme Q10 is indispensable for the production of cell energy in the mitochondria. Here, energy is formed from the carbohydrates, fat and protein in food, together with oxygen, in the form of adenosine triphosphate (ATP) ‒ the body’s own “energy currency”. This energy is, so to speak, the fuel for our cells.
During this process, Q10 transfers electrons between two protein complexes in the inner mitochondrial membrane and in doing so, it switches back and forth many times per second between the two forms of Q10, ubiquinone and ubiquinol. Without coenzyme Q10, the electron flow comes to a halt – the powerhouse of the cell then stands still.
The number of mitochondria in a cell of the body may greatly vary depending on the tissue and cell type. Cells which need a lot of energy also accordingly contain more mitochondria, e.g.:
• Liver cell: 500‒2.500
• Muscle cell: 2.000
• Nerve cell: 10.000
• Egg cell: > 100.000
The volume which the mitochondria occupy in the various cell types is also correspondingly different. This amount is, for example, a significant 36% in the case of heart muscle cells, and in liver cells, this is even 52% of the total cell volume. And the more mitochondria a cell has, the more Q10 it also contains.
Another interesting fact is that only a very small amount of the energy obtained (ATP) in the body can be stored and it therefore needs to be continuously formed anew. The amount of ATP which your cells use up on a daily basis corresponds to approximately your own body weight! Thus, if you weigh 70 kg, your cells form about 70 kg ATP every day.
A Q10 deficiency can develop because of various factors, for example due to:
- Competitive sports
- Weight-loss diets
- Low-fat food
- Taking certain medications, such as cholesterol-lowering drugs (statins) which can reduce the body’s own Q10 production
- Inadequate intake of micronutrients which are needed for the body’s own Q10 formation (e.g. vitamin B3, B6, B12, folic acid, pantothenic acid, selenium, zinc)
- A loss of Q10 in foods due to long transport and storage times, preservation, or extreme heating during cooking
- The continuous reduction in the body’s own Q10 formation starting at around age 20
There is also an increased need for Q10 in the case of some diseases*, such as:
- Chronic fatigue syndrome (CFS)
- Cardiovascular diseases
- Parkinson’s disease
- Alzheimer’s disease
- Diabetes mellitus
- Gastrointestinal disorders
- Gall bladder dysfunction
- Bronchial asthma
*This concerns an increased need, if applicable, and not the relief, cure or prevention of the disease.
Daily Requirement Of Coenzyme Q10
Q10 is formed by our body itself and also absorbed from food. We generally have about 0.5 to 2 g Q10 in our own body and in addition, around 5 to 10 mg should be absorbed from food every day. If there is an increased need for Q10, such as in the case of stress, competitive sports, and also with increasing age, it is recommended to consume Q10 at a dosage between 30 and 200 mg per day with a meal. From the age of 20, the body's own Q10 formation gradually decreases, so that an intake of 30 to 90 mg is recommended. If there is an increased need for Q10, such as in the case of stress and competitive sports, it is recommended to consume Q10 in a dosage of between 100 and 300 mg per day.
If you would like to know your coenzyme Q10 level, you can have it measured in your blood by your doctor or alternative practitioner.
The normal value is between 0.67 and 0.99 µg/ml blood. If you have an elevated cholesterol level or do not know this level exactly, then have your cholesterol-corrected coenzyme Q10 level measured in order to obtain a valid result. Q10 is present in the blood bound to cholesterol and thus high cholesterol values are automatically associated with higher Q10 values and may conceal a Q10 deficiency. In this measurement method, Q10 is correlated to cholesterol and should reach a value of at least 0.2 µmol/mmol cholesterol.
Q10 Foods: These Are The Best Sources Of Coenzyme Q10
Q10 is found in various foods, in particular in the following:
• Meat (beef, poultry, liver)
• Fish (especially in sardines)
• Some vegetable oils
• Nuts and almonds
• Green vegetables
However it would be necessary to consume, for example, approx. 3 kg beef, 1.5 kg peanuts, 10 kg broccoli or about 60 avocados to meet the daily need. Therefore, to adequately supply the body, supplementation with a natural Q10 preparation is recommended in addition to a healthy diet. Studies show that, in healthy volunteers, administering 30 mg Q10 per day for 6 weeks can cause the cholesterol-corrected Q10 value to increase from 0.16 to 0.33 µmol/mmol cholesterol.
Which Q10 product does TISSO have?
The product Pro Q10 Spectrum from TISSO combines both forms of coenzyme Q10 (ubiquinone and ubiquinol) in a capsule. The forms are usefully complemented by a mixture of polyphenols from a total of 29 fruits, vegetables and herbs as well as the natural substance mumijo (shilajit) and vitamin B3. As a result, the numerous ingredients can have synergistic effects in the body – just as we also know from nature.
With optimal Q10 bioavailability!
Both Q10 forms ubiquinone and ubiquinol are found in Pro Q10 Spectrum as innovative branded raw materials with markedly high bioavailability in comparison to “conventional” Q10 raw materials:
Ubiquinone (CAVAQ10Ⓡ): 18-times better bioavailability through a patented complexing with natural cyclodextrins (ring-shaped carbohydrates from starch); as a result, ubiquinone becomes “water soluble” and more easily absorbable
Ubiquinol (from KanekaⓇ): 7-times better bioavailability through microencapsulation (natural coating); as a result, the sensitive ubiquinol is stable and protected from oxidation
With Q10 from natural production!
Die in Pro Q10 Spectrum enthaltenen Q10-Formen Ubiquinon und Ubiquinol stammen dank innovativer Verfahren aus natürlicher Fermentation und entsprechen somit zu 100% dem körpereigenen Q10 (trans-Form).
Synergy effects used!
In Pro Q10 Spectrum, Q10 is usefully combined with a comprehensive polyphenol mixture from a total of 29 fruits, vegetables and herbs as well as the natural substance mumijo (shilajit) and vitamin B3 in a capsule in order to harness synergy effects for the body.
The variety of the ingredients from the 29 fruits, vegetables and herbs of the branded raw material SPECTRATM cover a very broad spectrum of polyphenols that complement and support each other in their effects. Polyphenols are valuable secondary plant substances.
The high-quality shilajit (from PrimaVie®) comes from the Himalayas and, as a humus-like substance containing minerals, has 50% fulvinic acid and more than 40 different minerals, among others. Shilajit has been an inherent part of Ayurvedic medicine for a long time. In addition, studies show that shilajit stabilises Q10 in its ubiquinol form.
The vitamin B3 (niacinamide) contained in Pro Q10 Spectrum promotes healthy energy metabolism and normal function of the nervous system and mind, among others. It also supports the regeneration processes of the body.
Coenzyme Q10 In Maximum Bioavailability
Q10 lets the cells really breathe properly. The coenzyme is indispensable for energy production in the mitochondria. TISSO now offers the essential nutrient in a completely new formulation – thanks to ultramodern, innovative raw materials with much higher bioavailability than before.
Spectrum with Q10 from Kaneka Ubiquinol™ and CAVAQ10® ubiquinone
- with 75 mg ubiquinone and 25 mg ubiquinol per daily dose, provides
three times more Q10 than our previous product Pro Q10 Plus.
- with its unique combination of 18x bioavailable CAVAQ10® ubiquinone and up to 7x bioavailable Kaneka Ubiquinol™ it ensures maximum ubiquinone absorption. "
- additionally contains synergistically active ingredients:
mumijo, plant-based polyphenols, and niacinamide (vitamin B3).
- Kalén, A., Appelkvist, E. L. & Dallner, G. Age-related changes in the lipid compositions of rat and human tissues. Lipids 24, 579–584 (1989).
- Gröber, U. Mikronährstoffe: Beratungsempfehlungen für die Praxis. (Wissenschaftliche Verlagsgesellschaft mbH Stuttgart, 2006).
- Kuklinski, M. B. & Schemionek, A. Mitochondrien: Symptome, Diagnose und Therapie. (Aurum Verlag, 2016).
- Kuklinski, B. & Schemionek, A. Mitochondrientherapie - die Alternative. (Aurum in Kamphausen Media GmbH, Bielefeld, 2018).
- Gröber, U. Mikronährstoffe: Metabolic Tuning-Prävention-Therapie; mit 134 Tabellen. (Wissenschaftliche Verlagsgesellschaft mbH Stuttgart, 2012).
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