Coenzyme Q10


Author: Dr. Beate Fuchs ‎‏‏‎ ‎‏‏‎ ‎|‏‏‎ ‎‏‏‎ ‎‏‏‎Published: 03. June 2020‎‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎|‏‏‎ ‎‏‏‎ ‎‏‏‎ Updated: 10. May 2021

 

Coenzyme Q10

Tisso Blatt Trennlinie Mitochondrien Sekundäre Pflanzenstoffe

Why this coenzyme is so important for the body

Coenzyme Q10, also abbreviated as Q10, was known primarily through the cosmetic industry. However, it is important not only for our skin, but also for every one of the approximately 37 billion cells in our body. It is found in particular in the “powerhouses of the cells” ‒ the mitochondria ‒ where around 90% of all of the energy for our body is produced. And this energy is used for nearly all of the processes in our body – without energy, these processes cannot run.

Our body can form Q10 itself, however studies show that the body’s own Q10 production continuously decreases starting at around age 20. Moreover, stress, competitive sports, an unhealthy lifestyle, smoking, and taking certain medications, for example, can increase this process. Apart from a healthy diet, taking a nutritional supplement may be useful to systematically counteract a Q10 deficiency.

Why this coenzyme is so important for the body

Coenzym Q10
Ubiquinol and ubiquinone – the difference
Q10 effect
Q10 deficiency
Daily requirement of coenzyme Q10
Q10 foods

Coenzym Q10 Coenzyme Q10

Tisso Blatt Trennlinie Mitochondrien Sekundäre Pflanzenstoffe

Coenzyme Q10 was discovered in 1955 and it is a fat-soluble, vitamin-like substance which can be produced by our body itself and which is also ingested through food. It is an odourless, tasteless crystalline substance which belongs to the ubiquinone family.

Q10 is found in all cells of the body and in the mitochondria in particular. Vital energy is formed in the mitochondria from food. Organs with a high energy requirement, such as the heart, brain, muscles, liver and kidneys, have a particularly high concentration of Q10.

Q10 is also notably present in membranes which surround the inside of cells and cell organelles like a shell. The exchange of substances such as sodium, potassium and calcium ions and the transfer of information, among other things, are regulated via these membranes. Q10 – along with the also valuable omega-3 fatty acids – largely determines the quality of the membranes.

Q10 ist in allen Körperzellen ‒ außer den roten Blutkörperchen ‒ zu finden und dort vor allem in den Mitochondrien. In diesen wird aus der Nahrung die lebenswichtige Energie gebildet. Organe mit einem hohen Energiebedarf wie Herz, Gehirn, Muskeln, Leber und Nieren weisen eine besonders hohe Konzentration an Q10 auf.

Ubiquinol und Ubiquinon – Unterschied Ubiquinol And Ubiquinone – The Difference

Tisso Blatt Trennlinie Mitochondrien Sekundäre Pflanzenstoffe

Coenzyme Q10 is present in our body in two biochemical forms: in the oxidised form as ubiquinone which is conventionally also simply referred to as coenzyme Q10, and also as ubiquinol in the reduced form. Both forms play a role in energy production in the mitochondria. In other areas of the body, such as in the blood and lymph, around 90% of Q10 is present in the reduced form as ubiquinol.

In our body, Q10 is primarily formed in the liver, however this is also fundamentally possible in all other organs and tissues.

In a multistep process, Q10 arises in the form of ubiquinone from mevalonic acid and the amino acids tyrosine and methionine as well as with the aid of vitamins B3, B6, B12, folic acid and pantothenic acid.

During energy production in the mitochondria, ubiquinone, as a mobile transport molecule, can absorb electrons from one protein complex and transfer them to another. This results in ubiquinol which becomes ubiquinone once again after releasing the electrons and which is ready to absorb electrons again.

Q10-WirkungQ10 Effect

Tisso Blatt Trennlinie Mitochondrien Sekundäre Pflanzenstoffe

Coenzyme Q10 is indispensable for the production of cell energy in the mitochondria. Here, energy is formed from the carbohydrates, fat and protein in food, together with oxygen, in the form of adenosine triphosphate (ATP) ‒ the body’s own “energy currency”. This energy is, so to speak, the fuel for our cells.

During this process, Q10 transfers electrons between two protein complexes in the inner mitochondrial membrane and in doing so, it switches back and forth many times per second between the two forms of Q10, ubiquinone and ubiquinol. Without coenzyme Q10, the electron flow comes to a halt – the powerhouse of the cell then stands still.

The number of mitochondria in a cell of the body may greatly vary depending on the tissue and cell type. Cells which need a lot of energy also accordingly contain more mitochondria, e.g.:
• Liver cell: 500‒2.500
• Muscle cell: 2.000
• Nerve cell: 10.000
• Egg cell: > 100.000

The volume which the mitochondria occupy in the various cell types is also correspondingly different. This amount is, for example, a significant 36% in the case of heart muscle cells, and in liver cells, this is even 52% of the total cell volume. And the more mitochondria a cell has, the more Q10 it also contains.

Another interesting fact is that only a very small amount of the energy obtained (ATP) in the body can be stored and it therefore needs to be continuously formed anew. The amount of ATP which your cells use up on a daily basis corresponds to approximately your own body weight! Thus, if you weigh 70 kg, your cells form about 70 kg ATP every day.

Vitamin D3 WirkungQ10 Deficiency

Tisso Blatt Trennlinie Mitochondrien Sekundäre Pflanzenstoffe

A Q10 deficiency can develop because of various factors, for example due to:

  • Stress
  • Competitive sports
  • Weight-loss diets
  • Low-fat food
  • Smoking
  • Taking certain medications, such as cholesterol-lowering drugs (statins) which can reduce the body’s own Q10 production
  • Inadequate intake of micronutrients which are needed for the body’s own Q10 formation (e.g. vitamin B3, B6, B12, folic acid, pantothenic acid, selenium, zinc)
  • A loss of Q10 in foods due to long transport and storage times, preservation, or extreme heating during cooking
  • The continuous reduction in the body’s own Q10 formation starting at around age 20

There is also an increased need for Q10 in the case of some diseases*, such as:

  • Burnout
  • Chronic fatigue syndrome (CFS)
  • Cardiovascular diseases
  • Parkinson’s disease
  • Alzheimer’s disease
  • Migraines
  • Fibromyalgia
  • Diabetes mellitus
  • Gastrointestinal disorders
  • Gall bladder dysfunction
  • Bronchial asthma
  • Infertility

*This concerns an increased need, if applicable, and not the relief, cure or prevention of the disease.

Vitamin d3Daily Requirement Of Coenzyme Q10

Tisso Blatt Trennlinie Mitochondrien Sekundäre Pflanzenstoffe

Q10 is formed by our body itself and also absorbed from food. We generally have about 0.5 to 2 g Q10 in our own body and in addition, around 5 to 10 mg should be absorbed from food every day. If there is an increased need for Q10, such as in the case of stress, competitive sports, and also with increasing age, it is recommended to consume Q10 at a dosage between 30 and 200 mg per day with a meal. From the age of 20, the body's own Q10 formation gradually decreases, so that an intake of 30 to 90 mg is recommended. If there is an increased need for Q10, such as in the case of stress and competitive sports, it is recommended to consume Q10 in a dosage of between 100 and 300 mg per day.
If you would like to know your coenzyme Q10 level, you can have it measured in your blood by your doctor or alternative practitioner.

The normal value is between 0.67 and 0.99 µg/ml blood. If you have an elevated cholesterol level or do not know this level exactly, then have your cholesterol-corrected coenzyme Q10 level measured in order to obtain a valid result. Q10 is present in the blood bound to cholesterol and thus high cholesterol values are automatically associated with higher Q10 values and may conceal a Q10 deficiency. In this measurement method, Q10 is correlated to cholesterol and should reach a value of at least 0.2 µmol/mmol cholesterol.

Vitamin d3 Q10 Foods: These Are The Best Sources Of Coenzyme Q10

Tisso Blatt Trennlinie Mitochondrien Sekundäre Pflanzenstoffe

Q10 is found in various foods, in particular in the following:
• Meat (beef, poultry, liver)
• Fish (especially in sardines)
• Eggs
• Some vegetable oils
• Legumes
• Nuts and almonds
• Green vegetables

However it would be necessary to consume, for example, approx. 3 kg beef, 1.5 kg peanuts, 10 kg broccoli or about 60 avocados to meet the daily need. Therefore, to adequately supply the body, supplementation with a natural Q10 preparation is recommended in addition to a healthy diet. Studies show that, in healthy volunteers, administering 30 mg Q10 per day for 6 weeks can cause the cholesterol-corrected Q10 value to increase from 0.16 to 0.33 µmol/mmol cholesterol.

What is important when selecting a Q10 product?

Tisso Blatt Trennlinie Mitochondrien Sekundäre Pflanzenstoffe

Pay attention to high bioavailability! Conventional Q10 (ubiquinone) as a powder in a capsule is only very poorly absorbed by the intestine ‒ approximately 5 to 8% maximum. This is related to its crystalline structure, its molecule size and its properties as a fat-soluble substance. However, if ubiquinone is packaged by a water-soluble, natural “shell”, it can be absorbed by the body significantly better. This can be achieved, for example, through complexing with cyclodextrins ‒ special ring-shaped carbohydrates obtained from plant starch. Moreover, Q10 is absorbed by the body about 3 to 4 times better in its reduced form, that is, as ubiquinol, than as the oxidised form ubiquinone. However, ubiquinol is very sensitive to oxygen and easily oxidises back into ubiquinone. This is why ubiquinol should always be protected from oxidation in Q10 products and be stable as a result.

Favour natural production!
Q10 can be produced synthetically as well as naturally through fermentation. Natural production has the advantage that it contains exclusively Q10 in what is known as the trans-form which corresponds exactly to the body’s own Q10. By contrast, the synthetic form contains not only the trans-form but up to 50% is also the exogenous cis-form.

Use synergy effects!
In nature, substances always exist in combination and not in isolation since they mutually complement each other and together they achieve a higher synergistic effect than the individual substances in total. This is why it is recommended to look for a useful combination of substances when selecting a nutritional supplement.

Which Q10 product does TISSO have?

Tisso Blatt Trennlinie Mitochondrien Sekundäre Pflanzenstoffe

The product Pro Q10 Spectrum from TISSO combines both forms of coenzyme Q10 (ubiquinone and ubiquinol) in a capsule. The forms are usefully complemented by a mixture of polyphenols from a total of 29 fruits, vegetables and herbs as well as the natural substance mumijo (shilajit) and vitamin B3. As a result, the numerous ingredients can have synergistic effects in the body – just as we also know from nature.

With optimal Q10 bioavailability!
Both Q10 forms ubiquinone and ubiquinol are found in Pro Q10 Spectrum as innovative branded raw materials with markedly high bioavailability in comparison to “conventional” Q10 raw materials:

Ubiquinone (CAVAQ10): 18-times better bioavailability through a patented complexing with natural cyclodextrins (ring-shaped carbohydrates from starch); as a result, ubiquinone becomes “water soluble” and more easily absorbable

Ubiquinol (from Kaneka): 7-times better bioavailability through microencapsulation (natural coating); as a result, the sensitive ubiquinol is stable and protected from oxidation

With Q10 from natural production!
Die in Pro Q10 Spectrum enthaltenen Q10-Formen Ubiquinon und Ubiquinol stammen dank innovativer Verfahren aus natürlicher Fermentation und entsprechen somit zu 100% dem körpereigenen Q10 (trans-Form).

Synergy effects used!
In Pro Q10 Spectrum, Q10 is usefully combined with a comprehensive polyphenol mixture from a total of 29 fruits, vegetables and herbs as well as the natural substance mumijo (shilajit) and vitamin B3 in a capsule in order to harness synergy effects for the body.

The variety of the ingredients from the 29 fruits, vegetables and herbs of the branded raw material SPECTRATM cover a very broad spectrum of polyphenols that complement and support each other in their effects. Polyphenols are valuable secondary plant substances.

The high-quality shilajit (from PrimaVie®) comes from the Himalayas and, as a humus-like substance containing minerals, has 50% fulvinic acid and more than 40 different minerals, among others. Shilajit has been an inherent part of Ayurvedic medicine for a long time. In addition, studies show that shilajit stabilises Q10 in its ubiquinol form.

The vitamin B3 (niacinamide) contained in Pro Q10 Spectrum promotes healthy energy metabolism and normal function of the nervous system and mind, among others. It also supports the regeneration processes of the body.

Coenzyme Q10 In Maximum Bioavailability

Tisso Blatt Trennlinie Mitochondrien Sekundäre Pflanzenstoffe

Q10 lets the cells really breathe properly. The coenzyme is indispensable for energy production in the mitochondria. TISSO now offers the essential nutrient in a completely new formulation – thanks to ultramodern, innovative raw materials with much higher bioavailability than before.

Spectrum with Q10 from Kaneka Ubiquinol™ and CAVAQ10® ubiquinone

  • with 75 mg ubiquinone and 25 mg ubiquinol per daily dose, provides
    three times more Q10 than our previous product Pro Q10 Plus.
  • with its unique combination of 18x bioavailable CAVAQ10® ubiquinone and up to 7x bioavailable Kaneka Ubiquinol™ it ensures maximum ubiquinone absorption. "
  • additionally contains synergistically active ingredients:
    mumijo, plant-based polyphenols, and niacinamide (vitamin B3).

Ohne Zusatzstoffe Glutenfrei Laktosefrei Fruktosefrei Schadstofffrei Natürliche Inhaltsstoffe Hefefrei Hypoallergen Vegetarisch

Literature

Tisso Blatt Trennlinie Mitochondrien Sekundäre Pflanzenstoffe

  • Kalén, A., Appelkvist, E. L. & Dallner, G. Age-related changes in the lipid compositions of rat and human tissues. Lipids 24, 579–584 (1989).
  • Gröber, U. Mikronährstoffe: Beratungsempfehlungen für die Praxis. (Wissenschaftliche Verlagsgesellschaft mbH Stuttgart, 2006).
  • Kuklinski, M. B. & Schemionek, A. Mitochondrien: Symptome, Diagnose und Therapie. (Aurum Verlag, 2016).
  • Kuklinski, B. & Schemionek, A. Mitochondrientherapie - die Alternative. (Aurum in Kamphausen Media GmbH, Bielefeld, 2018).
  • Gröber, U. Mikronährstoffe: Metabolic Tuning-Prävention-Therapie; mit 134 Tabellen. (Wissenschaftliche Verlagsgesellschaft mbH Stuttgart, 2012).

WE ARE HERE FOR YOU.

Tisso Blatt Trennlinie Mitochondrien Sekundäre Pflanzenstoffe

Tisso TelefonTEL.: +49 27 62 98 36 – 20 08

If you have any questions or would like to place an order, we are happy to help you personally.
You can reach us by phone from Monday - Friday 9:00 - 17:00.

Tisso WhatsApp +49 (0) 27 62 - 98 36 - 0

If you have any questions, please do not hesitate to contact us.

Tisso Mail orders@tisso.de

You can email us at any time. We will reply within one working day.

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Guide to prebiotics


Author: Dr. Beate Fuchs ‎‏‏‎ ‎‏‏‎ ‎|‏‏‎ ‎‏‏‎ ‎‏‏‎Published: 06. April 2021‎‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎|‏‏‎ ‎‏‏‎ ‎‏‏‎ Updated: 07. May 2021

 

Prebiotics

Nutrition for your gut bacteria

Unlike probiotic bacteria, prebiotics are not living organisms, but instead are the “food” for the good gut bacteria. Prebiotics are special soluble fibre which people themselves cannot digest with their enzymes. They therefore reach the large intestine via the stomach and small intestine in an undigested state where they serve as food for the bacteria.

At the same time, they support digestion and normal bowel movements. Apart from the soluble fibre, there is also insoluble fibre that cannot be utilised by the bacteria, however it has a positive effect on gut activity.

Nahrung für Ihre Darmbakterien

Effect of prebiotics
Prebiotic foods
Insoluble fibre
High-fibre diet
Buying prebiotics
Prebiotics from TISSO

Effect of prebiotics Effect of prebiotics

Prebiotic food components are indigestible, water-soluble fibre such as pectin, inulin or oligofructose from plant-based foods. While the gut cells do not have any appropriate enzyme for breaking these components down, they are urgently needed by the gut bacteria to be able to live.

This leads to:
• an increase in “good” bacteria, such as bifidobacteria and lactobacilli
• improvement of the gut environment
• stabilisation and regeneration of the intestinal mucosa through the production of short-chain fatty acids

• strengthening of the intestinal barrier to protect against harmful bacteria and harmful substances
• better absorption of calcium, sodium, magnesium and phosphorus
• improvement in bowel movements
• strengthening of the immune system

Welche Darmbakterien gibt es und welchen Einfluss haben sie auf die Gesundheit? Prebiotic foods

Soluble fibre is found in plant-based foods, especially in fruit and vegetables. The following are particularly rich in this type of fibre:
• Artichokes
• Onions
• Bananas
• Leeks
• Garlic
• Chicory root

Not everyone tolerates all fibre equally well. A lot of soluble fibre is quickly broken down by the gut flora, which may lead to a lot of gas – a frequent cause of bloating, feelings of fullness and stomach pain.

For this reason, we at TISSO have developed a product which contains exclusively fibre which is utilised slowly in the gut and therefore is very well tolerated – even in cases of sensitive digestion.

Das Mikrobiom What is insoluble fibre and
what types are there?

Unlike soluble fibre, insoluble fibre such as cellulose and lignin are not prebiotic food components, however it is just as healthy for our gut in a different way. Firstly, it results in an increase in stool volume which in turn leads to better bowel activity. Since it is also satiating for a long time, both soluble and insoluble fibre should be a part of your diet, especially if you wish to lose weight.

Insoluble fibre-rich food components are found primarily in grains and legumes and should be on the menu more often due to their positive effect on the gut. Some of the best foods are:
• Psyllium husks
• Legumes
• Mushrooms
• Nuts
• Seeds (flax seeds)

ProbiotikaWhat are some tips for a high-fibre diet?

If you want to do something good for your gut flora, your diet should be made up of high-fibre foods. If you start the morning with muesli made from fruit and nuts, you can already begin consuming plenty of fibre even at the first meal of the day.

Mushrooms, vegetables, legumes and seeds (especially flaxseed) should regularly be on your menu.
Make a stew with lentils or beans more often, or regularly eat hummus with meals.

Fruit & vegetables:
Bananas
Baby spinach
Avocado
Broccoli
Kale

Legumes:
Lentils
Chickpeas
Peas
Beans
Whole-grain products:
Whole-grain bread
Whole-grain pasta
Brown rice
Oats
Nuts & Seeds:
Flaxseed
Sunflower seeds
Pumpkin seeds

Präbiotika Tips for choosing products

A good prebiotic is characterised by slow fermentation, thus a slow breakdown by bacteria in the gut. A lot of soluble fibre is fermented very quickly by the gut flora. This also produces a lot of gas very quickly. Slow fermentation, by contrast, ensures optimal tolerability.

The following types of soluble fibre are broken down very slowly and are thus particularly well tolerated even in cases of sensitive digestion:

● Partially hydrolysed guar gum (PHGG)
● Acacia fibre
● Resistant dextrin (RS4)
● α-gluco-oligosaccharides

PräbiotikaThe prebiotic from TISSO

The unique fibre quartet

Pro Präbioma offers selected soluble fibre, optimally coordinated for balanced gut flora:

• Partially hydrolysed guar gum
• Acacia fibre
• Resistant dextrin
• α-gluco-oligosaccharides (GOSα)

Calcium and zinc, minerals important for metabolism and digestion, are added to the formulation.

Slow fermentation – outstanding tolerability

Not everyone tolerates all fibre equally well. A lot of soluble fibre is broken down very quickly by the gut flora. This also produces a lot of gas very quickly – a frequent cause of bloating, feelings of fullness and stomach pain.

Pro Präbioma contains exclusively fibre that is fermented slowly in the gut and is therefore very well tolerated, even in cases of sensitive digestion.

vegan Ohne Zusatzstoffe Hefefrei Fructosefrei Glutenfrei Hypoallergen Laktosefrei Natürliche Inhaltsstoffe Schadstofffrei

WE ARE HERE FOR YOU.

Tisso Blatt Trennlinie Mitochondrien Sekundäre Pflanzenstoffe

Tisso TelefonTEL.: +49 27 62 98 36 – 20 08

If you have any questions or would like to place an order, we are happy to help you personally.
You can reach us by phone from Monday - Friday 9:00 - 17:00.

Tisso WhatsApp +49 (0) 27 62 - 98 36 - 0

If you have any questions, please do not hesitate to contact us.

Tisso Mail orders@tisso.de

You can email us at any time. We will reply within one working day.

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Mitochondria


Autorin: Dr. Beate Fuchs ‎‏‏‎ ‎‏‏‎ ‎|‏‏‎ ‎‏‏‎ ‎‏‏‎Veröffentlicht am: 03. Juni 2020‎‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎|‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎Aktualisiert am: 10. Mai 2021

 

Mitochondria

Tisso Blatt Trennlinie Mitochondrien Sekundäre Pflanzenstoffe

Why mitochondria are so important

Without mitochondria, we would have no energy at all – life would not be possible. This is because these small “powerhouses” of our cells provide about 90% of vital energy. And this energy – like fuel – is needed for nearly all processes in our body, particularly in the muscles, the heart, the nervous system, the brain, as well as the liver and kidneys, the detoxification organs.

Any decrease in energy is also felt the fastest at these sites. The question now is what mitochondria are exactly, which nutrients they need, and how they can be properly supported.

Why mitochondria are so important

Mitochondria – Profile
Mitochondria – Structure
Mitochondria – Function
Strengthening mitochondria
Multinutrient complex – Tips
What kind of multinutrient complex does TISSO have?

mitochondrien – Steckbrief What are mitochondria?

Tisso Blatt Trennlinie Mitochondrien Sekundäre Pflanzenstoffe

Mitochondria are very small components within each of the nearly 37 trillion cells in our body – with the exception of red blood cells. They are only about 1 µm wide and 2‒5 µm long, thus very small. However, 1.000 fragments are usually found in a cell, and even 2.000 in muscle cells and 10.000 in nerve cells. This is because the more energy a cell needs to be able to function well, the more mitochondria it also has, in general.

The main task of the mitochondria is, in particular, the production of energy from food – like a “power station”. And our body needs energy around the clock, even at night. For example, the heart beats around 100.000 times per day, and about 10.000 litres of air are inhaled per day by the lungs. Without mitochondria, nothing in our body would work.

Mitochondria – structure Mitochondria – structure

Tisso Blatt Trennlinie Mitochondrien Sekundäre Pflanzenstoffe

The mitochondria contain two sheaths which are also known as membranes. The outer membrane acts like a protective covering which can simultaneously allow certain substances to pass in and out. The inner membrane, by contrast, has many folds in its interior in order to maximise the surface area, because this is where energy production, for example, takes place – and more energy can typically be produced on a larger surface.

An important component of membranes and thus also for energy production in the mitochondria are polyunsaturated omega-3 fatty acids, especially EPA and DHA. In food, particularly large amounts of these are found in fatty fish such as mackerel, salmon and sardines, and also in krill oil. More information about omega-3 can be found here.

Mitochondria – functionMitochondria – function

Tisso Blatt Trennlinie Mitochondrien Sekundäre Pflanzenstoffe

We ingest carbohydrates, fat and protein from our food. These are broken down in our body into their individual components. However, for the body to be able to actually use the energy they contain, they must be converted into the body’s own “currency”. Behind this currency is the substance adenosine triphosphate (ATP), an extremely energy-rich compound. The production of this substance from ingested food primarily takes place in the mitochondria of the cells. And oxygen is needed for this process. This is why this is also referred to as “cell respiration”.

Other important processes take place in the mitochondria. These include, for example:
• the citrate cycle as the “metabolism centre” of the cell
• the breakdown of fatty acids (β-oxidation)
• thermogenesis, that is, the production of heat
• cell control (apoptosis), that is, the initiation of the breakdown of damaged cells
• a part of the formation of steroid hormones
• a part of the urea cycle

mitochondrien stärkenStrengthening mitochondria

Tisso Blatt Trennlinie Mitochondrien Sekundäre Pflanzenstoffe

In order for energy to actually be able to be produced from food, the mitochondria need certain micronutrients, such as vitamins, minerals, or trace elements, which assist in this task. In addition, mitochondria must be protected from harmful influences, especially from aggressive radicals, because they can damage protein components, enzymes, genetic material, and the sensitive membranes. As a result, the “power station” runs more poorly.

Radicals occur more frequently due to stress, sports, an unhealthy diet, and environmental toxins, for example. It is then even more important for the body to have sufficient amounts of so-called antioxidants in order to neutralise the radicals. Vitamin C, vitamin E, manganese, selenium, and zinc, for example, help protect the cells from oxidative stress.

In summary, particularly large amounts of the following micronutrients can be found in the mitochondria:
• B vitamins: B1, B2, B3, B6, B12, biotin, folic acid, pantothenic acid
• Coenzyme Q10 (the body’s own formation decreases starting at around age 20)
• Minerals: magnesium, calcium
• Trace elements: selenium, zinc, manganese, iron, sulphur
• Alpha-lipoic acid
• L-carnitine
• Omega-3 fatty acids (especially EPA, DHA)
• Vitamins C, D3 and E
• L-glutathione
• Taurine

If less energy is available to the body, this can be seen in particular in the muscles, heart, nervous system, and brain. This is because these organs need a very large amount of energy.

A lack of micronutrients can be caused by a variety of factors, such as:
• Persistent stress
• High-performance sports
• Unhealthy diet
• Preservatives, pesticides
• Heavy metals
• Smoking
• Ozone
• Excessive alcohol consumption
• Use of certain medications
• Pregnancy and breastfeeding
• Increasing age

Nutritional supplementation is a good idea for anyone with a deficiency in or an increased need for micronutrients or who wants to do something good for his or her body. In addition, moderate sports, high intensity interval training (HIIT) which is characterised by short and very intensive bursts of training, as well as exposure to cold have positive effects on the mitochondria. Adequate sleep and stress reduction are also important.

Multinutrient complex – tips Multinutrient complex – tips

Tisso Blatt Trennlinie Mitochondrien Sekundäre Pflanzenstoffe

The processes can run well only if there are adequate amounts of all necessary micronutrients in the mitochondria. This is because the weakest link in a chain ultimately determines the performance of the entire chain. To cover an increased need for these important micronutrients and provide the body with a sufficient supply, an appropriate combination of vital substances is helpful – a multinutrient complex.

Usefully combining various substances in a preparation also always has the advantage of the substances mutually complementing each other and achieving a greater synergistic effect together than the sum of individual substances. Nature gives us a good example, because in nature, substances only exist in combination and not in isolation. In addition to vitamins, minerals, trace elements, and protein components, secondary plant substances, such as polyphenols, and numerous other substances are also highly valuable.

What kind of multinutrient complex does TISSO have? What kind of multinutrient complex does TISSO have?

Tisso Blatt Trennlinie Mitochondrien Sekundäre Pflanzenstoffe

The product Pro Dialvit 44 is a multinutrient complex which contains a total of 33 valuable ingredients. In selecting the substances, special attention was paid to a useful combination of vitamins, trace elements, natural substances containing polyphenols, amino acids, as well as numerous other substances, such as coenzyme Q10, L-carnitine, taurine, lutein, curcumin, α-lipoic acid, shiitake mushrooms and yam.

The vitamins B1, B2, B3, B6, B12 and biotin they contain primarily contribute to a healthy energy metabolism and normal function of the nervous system and the mind. In addition, vitamins C, E and B2, as well as the trace elements selenium, zinc, and manganese protect the cells from oxidative stress. Vitamin E is additionally present in the form of a natural complex of d-α tocopherol and all four forms of tocotrienol. Vitamins B6, B12 and folic acid are included already in their metabolically active forms and contribute to normal homocysteine metabolism, among other things.

The natural substances containing polyphenols in Pro Dialvit 44 include turmeric powder, pomegranate extract, and grape seed extract. And yam primarily contains protein, vitamins, minerals, and the trace elements iron, copper, zinc, manganese, and sulphur. The lecithin it contains is rich in phosphatidylcholine, which is found primarily in the inner mitochondrial membrane.

This is where the important energy production takes place. Three different mushrooms are also combined in Pro Dialvit 44: Ling Zhi, known as “king of medicinal mushrooms”, along with the almond mushroom (Agaricus blazei Murill) and the shiitake mushroom.

The version for children: The product Pro Dialvit kids was developed as a multinutrient complex especially for children.

If there is a particularly high need for individual micronutrients, Pro Dialvit44 can be usefully supplemented even further with, for example:
Pro Vita B Complete: with the complete vitamin B spectrum
Pro Q10 Spectrum: with both forms of Q10 (ubiquinone + ubiquinol) plus a rich polyphenol mixture from 29 fruits, vegetables, and herbs
Pro Curmin Forte: with curcumin and turmerosaccharides from the valuable turmeric root, plus quercetin, ginger and black tea extract as well as vitamin C buffered to be easy on the stomach
Pro Omega Ultra: omega-3 fatty acids, especially EPA and DHA, plus vitamin E and astaxanthin

Sources

Tisso Blatt Trennlinie Mitochondrien Sekundäre Pflanzenstoffe

  • Gröber, U. Mikronährstoffe: Beratungsempfehlungen für die Praxis. (Wissenschaftliche Verlagsgesellschaft mbH Stuttgart, 2006).
  • Kuklinski, M. B. & Schemionek, A. Mitochondrien: Symptome, Diagnose und Therapie. (Aurum Verlag, 2016).
  • Little, J. P., Safdar, A. & Wilkin, G. P. A practical model of low‐volume high‐intensity interval training induces mitochondrial biogenesis in human skeletal muscle: potential mechanisms. The Journal of (2010).
  • Opichka, M., Shute, R., Marshall, K. & Slivka, D. Effects of exercise in a cold environment on gene expression for mitochondrial biogenesis and mitophagy. Cryobiology 90, 47–53 (2019).
  • Chung, N., Park, J. & Lim, K. The effects of exercise and cold exposure on mitochondrial biogenesis in skeletal muscle and white adipose tissue. J Exerc Nutrition Biochem 21, 39–47 (2017).

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Guide to probiotics


Autorin: Dr. Beate Fuchs ‎‏‏‎ ‎‏‏‎ ‎|‏‏‎ ‎‏‏‎ ‎‏‏‎Veröffentlicht am: 03. Juni 2020‎‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎|‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎Aktualisiert am: 10. Mai 2021

 

Probiotics

How you can support your health with gut bacteria

Probiotics are essential for a healthy gut. They keep gut flora in balance and can have positive effects on health. In addition, a strong immune system is significantly dependent on the healthy function of your gut. A healthy gut in turn requires intact gut flora which represents a unique interaction of innumerable gut bacteria, also known as the microbiome.

Apart from a variety of immune cells, our gut also houses a large number of nerve cells which is why it is rightly referred to as a “second brain”. Here we show you exactly what gut flora is, how it is connected to your well-being, and how you can promote healthy gut flora.

How you can support your health with gut bacteria

Probiotika-Wirkung
Gestörte Darmflora
Das Mikrobiom
Darmflora aufbauen
Probiotikum kaufen
Probiotikum von TISSO

Effect of probiotics Effect of probiotics

Probiotics contain "good", i.e. health-promoting intestinal bacteria and thus support the natural intestinal flora in its diverse functions.

Intact gut flora is important for:
● digestion
● gut motility
● immunomodulation
● the production of short-chain fatty acids
● the supply of vitamins
● physical and mental performance

Once the “bad” bacteria predominate, the gut flora can quickly become imbalanced and have a negative effect on our health.

What causes disrupted gut flora? What causes disrupted gut flora??

The causes of disrupted gut flora can be extremely diverse. The most common reason is an imbalanced and low-fibre diet primarily consisting of sugary foods, white flour, baked goods, fried foods, fast food and processed foods.

However, apart from diet, there are other factors which have a negative effect on gut health. For example, antibiotics can disrupt the colonisation of the gut and lead to a decrease in “good” bacteria. This is generally associated with an increase in pathogenic bacteria and can eventually have an effect on digestion and well-being. Environmental toxins which enter our organism directly or indirectly can cause gut problems as well. Persistent stress additionally exposes the body to exceptional circumstances and can also affect gut function.

The microbiome The microbiome

Did you know that, in general, bacteria make up about half of your body? According to the latest research, around 38 billion bacteria and other microorganisms are bustling about on and, in particular, in the human organism – more than one microbe per body cell. Only after a bowel movement with which one to two billion bacteria leave each time are the human cells briefly in the majority. Around 99 percent of our cohabitants live in the digestive tract, in the large intestine in particular. Together, they form the intestinal – that is, gut-based – microbiome.

The image of bacteria has changed. For a long time, they were considered almost exclusively to be intruders to be fought. Today, we know that we could not survive without them. We are so closely intertwined with them that researchers nowadays recognise the person and his/her microbiome to be a common, functional unit, a type of superorganism. Figuratively speaking, the bacteria, as tiny guests receiving “room and board”, support the gut in both of its critical tasks: digestion and immune defence.

Which gut bacteria are there?

The intestines of an adult are approximately 5.5 to 7.5 metres long and its surface area is about a hundred times larger than that of our skin. This gives an idea of how important the gut and thus also gut flora are. Our gut flora is colonised with both “good” and “bad” bacteria and as a whole, they are referred to as the microbiome.

The “good” gut bacteria include, for example,
lactobacilli and bifidobacteria
and the “bad” gut bacteria are, for example,
staphylococci and Clostridioides difficile.

A healthy person is assumed to have about 10 to 100 billion bacteria in the gut which comprise approximately 500 to 1,000 different species of bacteria and have a total weight of about 1-2 kilograms. Apart from this variety of bacteria, nearly 90 percent of immune cells are located in the gut, which makes it clear that the gut flora have a major influence on our immune system and our immune defences.

ProbiotikaBuilding up the gut flora

Probiotische Lebensmittel
Probiotics are living microorganisms which play a major role in our gut health and can build up healthy gut flora. They produce lactic acid which strengthens the “good” bacteria and keeps the “bad” bacteria in check. Probiotic bacteria of this type are found in fermented foods, for example:
● Yoghurt
● Kombucha
● Kefir
● Sauerkraut
● Tempeh

When it comes to probiotic bacteria, the focus is on two bacterial species in particular.

Lactobacilli
Lactobacilli – also referred to as lactic acid bacteria – are derived from the term “milk” (lactis), which in turn explains the function of these bacteria that live in the gut. They are primarily responsible for the production of lactic acid which contributes to a healthy gut environment and protects the gut from harmful bacteria.

Bifidobacteria
The name “bifidobacteria” comes from the Latin term “bifidus” which means “split or forked” and refers to its shape. Through the production of lactic acid, these bacteria can also protect us from pathogenic microbes. They are also responsible for the production of essential enzymes and vitamins and are therefore especially important for our health. Particularly in newborns, bifidobacteria play a major role for the immune system since they make up about 90 percent of gut flora.

Präbiotika What you should be aware of when buying a probiotic:

A good probiotic provides at least one billion microorganisms (109 CFU = colony-forming units) per daily dose and ideally contains as many bacterial strains as possible. Multispecies probiotics achieve far better results than preparations with only one culture or very few cultures.

For a broad spectrum of effects, there should above all be several substrains of lactobacilli and bifidobacteria, including some lactococcus, enterococcus or streptococcus species. Liquid probiotics with fermented plants and medicinal herbs contribute polyphenols which provide the gut bacteria with an additional benefit.

Welche Tipps gibt es für eine ballaststoffreiche Ernährung?Das Probiotikum von TISSO

Unser bewährtes PRO EM SAN

das Original – mit der einzigartigen Vielfalt an Milchsäurekulturen

• 31 hochdosierte, effektive Mikroorganismen-Stämme v. a. Bifido- und Lactobakterien
• 24 ausgewählte Kräuter- und Pflanzen-Extrakte

Lebende Mikroorganismen können sich aktiv gegen Magensäure schützen.

vegetarisch Ohne Zusatzstoffe Hefefrei Glutenfrei Hypoallergen Laktosefrei Natürliche Inhaltsstoffe Schadstofffrei

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Tisso Blatt Trennlinie Mitochondrien Sekundäre Pflanzenstoffe

Tisso TelefonTEL.: +49 (0) 27 62 - 98 36 - 0

If you have any questions or would like to place an order, we are happy to help you personally.
You can reach us by phone from Monday - Friday 9:00 - 17:00.

Tisso WhatsApp +49 (0) 27 62 - 98 36 - 0

If you have any questions, please do not hesitate to contact us.

Tisso Mail info@tisso.de

You can email us at any time. We will reply within one working day.

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Iodine – An underrated trace element

Iodine

An underrated trace element

When it comes to iodine, people are most likely to think of the thyroid and iodised table salt. But did you know that the female breast can store more iodine than the thyroid? Many organs in your body rely on the trace element.

Iodine is a vital trace element. The body needs only relatively small amounts of it, however it cannot create these amounts itself and instead they must be obtained from the diet. According to the German Nutrition Society, a healthy adult needs 200 microgrammes of iodine daily.

And this is not easy. Iodine is primarily found in the oceans, while the soil is comparatively low in iodine. Fruit, cereals and vegetables thus contain only small amounts of iodine. The proportion in animal-based foods such as eggs and milk is higher than before, due to iodine enrichment of animal feed. However, the absolute top sources are seaweed and saltwater fish. In this guide, you will learn which foods contain iodine and how you can identify and correct an iodine deficiency.

Foods that contain iodine
Iodine defiency
Daily iodine requirement
Effect of iodine
Taking iodine
Iodine - but naturally

bittere lebensmittelFoods that contain iodine

It is not only important for the body to take in sufficient amounts of iodine but also to supply the body with the auxiliary substances needed for the absorption and utilisation of iodine. It should also be borne in mind that certain substances can make it more difficult to absorb iodine, as explained in greater detail below.

Foods containing iodine - table
Iodine content in microgrammes/100 g
Laminaria
brown algae
300.000-1.100.000 Camembert 20
Kombu-
brown algae
170.000-260.000 Non-iodised
table salt
20
Wakame
brown algae
10.400-35.000 Mushrooms 18
Nori red algae 4.000-6.000 Broccoli 15
Iodised
table salt
2.000 Gouda
40% fat in dry mass
11
Haddock 272 Chicken egg 10
Cod 170 Whole milk 10
Lobster 100 Butter 4

Fellow combatants and rivals in the organism

What is more, there is occasionally a lack of important nutrients which are needed for the optimal absorption and utilisation of iodine. This is because the organism needs a number of auxiliary substances (cofactors) for the individual steps in iodine metabolism. In particular, these include selenium, iron and omega-3 fatty acids as well as vitamins A, C and D.

Conversely there are some substances which – if large quantities are consumed and the diet is simultaneously low in iodine – impair iodine uptake in the body or the formation of thyroid hormones. Since in this way they can cause an enlargement of the thyroid, they are known as goitrogens or strumigenic substances (from goitre and struma (Latin) = goitre).

The best known goitrogens include thiocyanates which are found, for example, in various vegetables of the brassica family (cabbage, Brussels sprouts, cauliflower, broccoli, kale, kohlrabi) but also in tobacco smoke. Soy and soy products contain goitre-promoting substances (isoflavones) which compete with the trace element if there is low iodine intake.

Other iodine rivals are bromine and fluorine. Both are chemically closely related to iodine and in the periodic table of the elements, they are together in the group of halogens. Fluoride, which is intended to protect the teeth from cavities, is found nowadays not only in almost every toothpaste but table salt is also enriched with it – in particular the combination of iodised salt with fluoride appears to be of little use, in view of the competition between the two elements.

Important source of iodine: iodised table salt

Iodised table salt has been approved in Germany since 1989 as a food and since then, it has significantly contributed to the supply of iodine. In contrast to Switzerland, Austria and the U.S., there is no statutory iodine prophylaxis in Germany (and thus also no “governmentally imposed mandatory iodation”, as many iodine critics maintain).

Iodised salt helps meet the need for iodine. Conversely, non-iodised sea salt is not a good source of iodine. The use in households, gastronomy and the food industry is by no means widespread. Around 80 percent of households but only about 30 percent of food manufacturers use iodised salt.

Incidentally, popular sea salt is not an alternative: sea salt is obtained by evaporating sea water and in the process, the iodine it contains is largely lost. If sea salt is not additionally iodised, it is nearly as low in iodine as non-iodised rock salt.

Tip: Iodised salt does not tolerate heat. During longer periods of boiling, for example, in noodle or potato water, a large portion of the iodine boils away. Thus it is best to salt your food only after it has been cooked.

Iodine from seaweed

By far, the most iodine-rich food is seaweed. It can accumulate the iodine compounds dissolved in sea water at high concentrations in its cells. Its natural iodine content exceeds not only that of all types of fruit and vegetables, but also that of saltwater fish and seafood.

An interesting alternative on your plate, however seaweed is available in this country almost exclusively in dried form. When buying seaweed, consumers should pay attention to its iodine content. With seaweed as a vegetable or salad, you can bring some interesting variety to your table. Be aware that the nutrient content and the iodine content in particular of individual types of seaweed can vary significantly. Some types contain up to 11,000 milligrammes iodine per kilogramme dry weight – however a large portion of the iodine can be lost, depending on the preparation method. To be able to estimate your iodine consumption, you should buy only seaweed products which contain clear information on the iodine content and maximum intake.

Jodmangel Iodine deficiency

Iodine deficiency is a global problem affecting approximately two billion people worldwide. Germany is now no longer among the areas identified as being iodine-deficient – the use of iodised table salt in households and industry and also the enrichment of animal feed have led to significantly higher intake in recent years – yet this doesn’t mean that the problem has been solved. A good third of Germans still do not get adequate amounts of the important trace element. The situation appears to even be worsening again and there is reason for concern, especially in the case of school-aged children: according to more recent studies, half of six- to twelve-year-olds do not get the recommended amount of iodine.

Symptoms of iodine deficiency

If the body is deficient in iodine over the long term, widely varying symptoms can develop. This is because iodine supports various processes and functions in the body. These include:
• normal production of thyroid hormones and healthy thyroid function
• normal energy metabolism
• healthy function of the nervous system
• normal cognitive function
• maintenance of healthy skin

Iodine saturation test

Those who would like to know the status of their own iodine intake can have it determined using blood and urine tests. However, the result is only indicative of the iodine supply of the thyroid.

A relatively new method to be able to better estimate the body’s own total requirement is the iodine saturation test developed by two American doctors. In this test, 50 milligrammes of iodine are first administered orally – the amount which is estimated to be normally stored in the body. If the organism has an optimal supply, it excretes at least 90 percent of this amount of iodine via the urine. Conversely, if it retains more than 10 percent, this is considered to be an indication of an iodine deficiency.

Jod Tagesbedarf – Wie viel Jod benötige ich täglich? Daily iodine requirement –
How much iodine do I need daily?

“Recommended intake” covers only the needs of the thyroid

The German Nutrition Society (DGE) recommends that adults consume 200 microgrammes of iodine daily and that pregnant and breastfeeding women consume 230 and 260 microgrammes, respectively.

To reach these quantities, according to the DGE, milk and dairy products should be consumed daily and saltwater fish once to twice per week (an important source also for omega-3 fatty acids) and iodised salt should be used consistently when preparing food.

Germans in fact consume an average of barely 125 microgrammes of iodine per day. Experts now also estimate the actual need for iodine to be far higher.

This is because the quantities recommended are sufficient only for the thyroid and many other organs also rely on this trace element.

Even the amount of iodine recommended by the DGE is hard for healthy adults to meet. It is even more difficult for persons with an increased need. Apart from pregnant and breastfeeding women, groups of people at risk of iodine deficiency also include children and adolescents, as well as vegetarians and vegans.

das hilft beim verdauen Effect of iodine

The vital trace element iodine fulfils numerous tasks in our body. Among other things, it supports:

• normal production of thyroid hormones and healthy thyroid function
• normal energy metabolism
• healthy function of the nervous system

• normal cognitive function
• maintenance of healthy skin

Taking iodine Taking iodine

The daily iodine requirement can generally not be met by diet alone. For this reason, the additional intake of iodine in the form of nutritional supplements is very helpful and recommended.

What should you be aware of when buying an iodine preparation?

Since seaweed may absorb not only iodine but also heavy metals and radioactive substances from ocean water, you should pay attention to the origin. Atlantic seaweed from European cultivation or – even better – from sustainable wild collection is, as a rule, monitored very carefully for possible contaminants.

Particularly in the case of an increased need for iodine or an identified iodine deficiency which cannot be met by a diet focusing on iodine intake, high-quality nutritional supplements from seaweed with a precisely defined dose of iodine are a good choice.

das hilft beim verdauenIodine – but naturally

Pro Iodine
Pro Iodine provides valuable natural iodine from North Atlantic knotted wrack – combined with high-quality astaxanthin obtained from the freshwater microalgae Haematococcus pluvialis (blood rain algae).

Best quality and safe raw material origins
All algae raw materials in Pro Iodine undergo strict quality and pollutant testing. The seaweed Seagreens® Ascophyllum nodosum (knotted wrack) comes from ecologically sustainable wild collection (certified according to the Nutritious Food Seaweed Standard).

ohne Zusatzstoffe Glutenfrei Laktosefrei Fruktosefrei Frei von Schadstoffen Natürliche Inhaltsstoffe Hefefrei Hypoallergen Vegetarisch

THE PERFECT ALGAE DUO:
Knotted wrack and blood rain algae

Larger amounts of iodine are present in nature almost exclusively in the ocean. Seaweed can store the iodine compounds dissolved in the water in high concentrations in its cells.

The iodine in Pro Iodine comes from the knotted wrack Ascophyllum nodosum, a species of brown algae prevalent mainly in the North Atlantic. Our raw material Seagreens® Ascophyllum nodosum is harvested in controlled and ecologically sustainable wild collection and is certified according to the Nutritious Food Seaweed Standard.

Haematococcus pluvialis is the most important natural source of astaxanthin. With the aid of this carotenoid, the freshwater microalgae can survive even under difficult environmental conditions. If there is a lack of nutrients or strong sun exposure, they switch into a resting stage and produce large amounts of astaxanthin to protect themselves against UV light and oxidation.

Free astaxanthin is sensitive to oxidation and for this reason, we protect the raw ingredient in Pro Iodine through particularly stable microencapsulation

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Curcumin – The guide


Author: Dr. Beate Fuchs ‎‏‏‎ ‎‏‏‎ ‎|‏‏‎ ‎‏‏‎ ‎‏‏Published: 11. March 2021‎‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎|‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎Updated: 4. August 2021

Curcumin

Tisso Blatt Trennlinie Mitochondrien Sekundäre Pflanzenstoffe

The valuable substance from nature

Bright yellow turmeric originally comes from India and southeast Asia and is nowadays considered to be the “world’s healthiest spice” or also the “spice of life”. It is also the main component in well-known curry powder and is obtained from the tuber of the turmeric plant.

However, turmeric is far more than just a spice and it has been used for a long time for traditional applications. This is because it contains the potent polyphenol curcumin as a biologically active ingredient which is also available today as a nutritional supplement in concentrated form and with high bioavailability. In this guide, you can learn what exactly is behind this and with which other natural substances this valuable substance should ideally be combined.

The valuable substance from nature

Curcumin and turmeric
Curcumin – Effect
Curcumin dosage
Curcumin-Aufnahme
Curcumin-Präparate
Curcumin von TISSO

Curcumin and turmeric – What is the difference? Curcumin and turmeric –
What is the difference?

Tisso Blatt Trennlinie Mitochondrien Sekundäre Pflanzenstoffe

Turmeric, also known as yellow root or Indian saffron, refers to the complete plant which belongs to the ginger family. It is cultivated in tropical climate zones, primarily in India and southeast Asia, and it grows up to two metres tall. The root stock (rhizome) needs a year until it is mature and it is characterised by its intense yellow-orange colour.

The peeled root stock is used fresh, dried or ground as a spice, flavouring or dye in the food and also cosmetic industry. Its bright yellow colour is due to the valuable ingredient curcumin as well as two other curcumin-like substances which are known jointly as curcuminoids. They make up a proportion of 3-5% in turmeric powder in which curcumin is primarily present and the curcuminoid mixture is therefore often simply referred to as curcumin. The curcuminoids belong to the biologically active components of the turmeric root.

Gemahlenes Kurkuma aus der Kurkuma-Wurzel mit seiner typisch gelb leuchtenden Farbe durch den Inhaltsstoff Curcumin

Ground turmeric from the turmeric root with its typical bright yellow colour due to the ingredient curcumin

Curcumin WirkungCurcumin – Effect

Tisso Blatt Trennlinie Mitochondrien Sekundäre Pflanzenstoffe